Promoting physical activity and physical function in people with long-term conditions in primary care: the Function First realist synthesis with co-design

Background: As people age and accumulate long-term conditions, their physical activity and physical function declines, resulting in disability and loss of independence.Primary care is well placed to empower individuals and communities to reduce this decline; however, the best approach is uncertain.Objectives: To develop a programme theory to explai

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Allele-specific methylation in the FADS genomic region in DNA from human saliva, CD4+ cells, and total leukocytes

Abstract Background Genetic variants within the fatty acid desaturase (FADS) gene cluster (human Chr11) are important regulators of long-chain (LC) polyunsaturated fatty acid (PUFA) biosynthesis in the liver and consequently have been associated with circulating LC-PUFA levels.More recently, epigenetic modifications such as DNA methylation, particu

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